InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Panx1

Summary

InnateDB Gene

IDBG-134948.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Panx1

Gene Name

pannexin 1

Synonyms

AI847747

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031934

Encoded Proteins

IDBP-134950

pannexin 1

IDBP-620313

pannexin 1

IDBP-620314

pannexin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110218:
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:15005161-15045478

Strand

Reverse strand

Band

Transcripts

ENSMUST00000056755	ENSMUSP00000053557
ENSMUST00000164273	ENSMUSP00000126405
ENSMUST00000166933
ENSMUST00000169288	ENSMUSP00000132764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005243	gap junction channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015267	channel activity
GO:0022840	leak channel activity
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding
GO:0055077	gap junction hemi-channel activity
GO:0097110	scaffold protein binding

Biological Process

GO:0002931	response to ischemia
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007267	cell-cell signaling
GO:0033198	response to ATP
GO:0034214	protein hexamerization
GO:0050715	positive regulation of cytokine secretion
GO:0050717	positive regulation of interleukin-1 alpha secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032059	bleb
GO:0043234	protein complex