Mus musculus Protein: Lats2
Summary
InnateDB Protein IDBP-620331.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lats2
Protein Name large tumor suppressor 2
Synonyms 4932411G09Rik; AV277261; AW228608;
Species Mus musculus
Ensembl Protein ENSMUSP00000133680
InnateDB Gene IDBG-168883 (Lats2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0009755 hormone-mediated signaling pathway
GO:0030216 keratinocyte differentiation
GO:0034613 cellular protein localization
GO:0035329 hippo signaling
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0046620 regulation of organ growth
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1354386
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00165
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UXG3
UniProt Splice Variant
Entrez Gene 50523
UniGene Mm.408428
RefSeq XP_006519287
MGI ID
MGI Symbol Lats2
OMIM
CCDS
HPRD
IMGT
EMBL AC154504
GenPept