InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGF3

Summary

InnateDB Protein

IDBP-62038.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF3

Protein Name

fibroblast growth factor 3

Synonyms

HBGF-3; INT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000334122

InnateDB Gene

IDBG-62036 (FGF3)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. {ECO:0000269PubMed:8663044}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Deafness with labyrinthine aplasia, microtia and microdontia (LAMM) [MIM:610706]: Unique autosomal recessive syndrome characterized by type I microtia, microdontia, and profound congenital deafness associated with a complete absence of inner ear structures (Michel aplasia). {ECO:0000269PubMed:17236138, ECO:0000269PubMed:18435799}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001759	organ induction
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009653	anatomical structure morphogenesis
GO:0030916	otic vesicle formation
GO:0036342	post-anal tail morphogenesis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048538	thymus development
GO:0048752	semicircular canal morphogenesis
GO:0051781	positive regulation of cell division
GO:0055026	negative regulation of cardiac muscle tissue development