Homo sapiens Gene: FGF3
Summary
InnateDB Gene IDBG-62036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF3
Gene Name fibroblast growth factor 3
Synonyms HBGF-3; INT2;
Species Homo sapiens
Ensembl Gene ENSG00000186895
Encoded Proteins
fibroblast growth factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69810224-69819024
Strand Reverse strand
Band q13.3
Transcripts
ENST00000334134 ENSP00000334122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001759 organ induction
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009653 anatomical structure morphogenesis
GO:0030916 otic vesicle formation
GO:0036342 post-anal tail morphogenesis
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048538 thymus development
GO:0048752 semicircular canal morphogenesis
GO:0051781 positive regulation of cell division
GO:0055026 negative regulation of cardiac muscle tissue development
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Activated point mutants of FGFR2 pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
FRS2-mediated cascade pathway
Phospholipase C-mediated cascade pathway
FGFR2b ligand binding and activation pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
FGFR1b ligand binding and activation pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Negative regulation of FGFR signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
FGFR1 ligand binding and activation pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Melanoma pathway
INOH
GPCR signaling pathway
FGF signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P11487
TrEMBL
UniProt Splice Variant
Entrez Gene 2248
UniGene Hs.37092
RefSeq NM_005247
HUGO HGNC:3681
OMIM 164950
CCDS CCDS8195
HPRD 01289
IMGT
EMBL BC113739 X14445
GenPept AAI13740 CAA32615
RNA Seq Atlas 2248