Version 5.4
Mus musculus Protein: Tbc1d24
Summary
InnateDB Protein IDBP-621031.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbc1d24
Protein Name TBC1 domain family, member 24
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128868
InnateDB Gene IDBG-145425 (Tbc1d24)
Protein Structure
UniProt Annotation
Function May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. {ECO:0000269PubMed:20727515}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Partially expressed at the plasma membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, particularly at the level of the cortex and the hippocampus. Expressed in the inner ear in spiral ganglion cells, a collection of neurons critical for hearing and balance. {ECO:0000269PubMed:20727515, ECO:0000269PubMed:24387994}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005097 Rab GTPase activator activity
Biological Process
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2443456
InterPro IPR000195 Rab-GTPase-TBC domain
IPR006571 TLDc
PFAM PF00566
PF07534
PRINTS
PIRSF
SMART SM00164
SM00584
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UUG6
PhosphoSite PhosphoSite-Q3UUG6
TrEMBL
UniProt Splice Variant
Entrez Gene 224617
UniGene Mm.301585
RefSeq NP_001157322
MGI ID
MGI Symbol Tbc1d24
OMIM
CCDS CCDS28477
HPRD
IMGT
EMBL AK049306 AK049754 AK083833 AK084693 AK086293 AK129304 AK138431 AK147647 AK161054 BC080845 BC094417
GenPept AAH80845 AAH94417 BAC33671 BAC33904 BAC39035 BAC39255 BAC39644 BAC98114 BAE23659 BAE28046 BAE36174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca