InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MME

Summary

InnateDB Protein

IDBP-62121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MME

Protein Name

membrane metallo-endopeptidase

Synonyms

CALLA; CD10; NEP; SFE;

Species

Homo sapiens

Ensembl Protein

ENSP00000353679

InnateDB Gene

IDBG-62119 (MME)

Protein Structure

UniProt Annotation

Function

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. {ECO:0000269PubMed:15283675, ECO:0000269PubMed:20876573, ECO:0000269PubMed:2531377}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	83 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042277	peptide binding

Biological Process

GO:0001822	kidney development
GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0019233	sensory perception of pain
GO:0044267	cellular protein metabolic process
GO:0046449	creatinine metabolic process
GO:0050435	beta-amyloid metabolic process
GO:0071345	cellular response to cytokine stimulus
GO:0071492	cellular response to UV-A
GO:0071493	cellular response to UV-B
GO:0090399	replicative senescence

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome