Homo sapiens Gene: MME
Summary
InnateDB Gene IDBG-62119.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MME
Gene Name membrane metallo-endopeptidase
Synonyms CALLA; CD10; NEP; SFE;
Species Homo sapiens
Ensembl Gene ENSG00000196549
Encoded Proteins
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
membrane metallo-endopeptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85%% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5\' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:155024124-155183729
Strand Forward strand
Band q25.2
Transcripts
ENST00000360490 ENSP00000353679
ENST00000382989 ENSP00000372450
ENST00000492661 ENSP00000420389
ENST00000460393 ENSP00000418525
ENST00000491597
ENST00000481828 ENSP00000420101
ENST00000462745 ENSP00000419653
ENST00000493237 ENSP00000417079
ENST00000491026 ENSP00000418791
ENST00000473730 ENSP00000420542
ENST00000497890 ENSP00000418238
ENST00000462837 ENSP00000417595
ENST00000477669
ENST00000495577
ENST00000493888
ENST00000615825 ENSP00000478173
ENST00000616757 ENSP00000480349
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 83 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
Biological Process
GO:0001822 kidney development
GO:0002003 angiotensin maturation
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0019233 sensory perception of pain
GO:0044267 cellular protein metabolic process
GO:0046449 creatinine metabolic process
GO:0050435 beta-amyloid metabolic process
GO:0071345 cellular response to cytokine stimulus
GO:0071492 cellular response to UV-A
GO:0071493 cellular response to UV-B
GO:0090399 replicative senescence
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0044306 neuron projection terminus
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of Angiotensinogen to Angiotensins pathway
Metabolism of proteins pathway
Peptide hormone metabolism pathway
KEGG
Renin-angiotensin system pathway
Hematopoietic cell lineage pathway
Protein digestion and absorption pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.307734 Hs.616835
RefSeq NM_000902 NM_007287 NM_007288 NM_007289 XM_006713646 XM_006713647
HUGO
OMIM
CCDS CCDS3172
HPRD 00392
IMGT
EMBL
GenPept
RNA Seq Atlas