Version 5.4
Mus musculus Protein: Awat2
Summary
InnateDB Protein IDBP-621771.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Awat2
Protein Name acyl-CoA wax alcohol acyltransferase 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128516
InnateDB Gene IDBG-161978 (Awat2)
Protein Structure
UniProt Annotation
Function Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity
GO:0050252 retinol O-fatty-acyltransferase activity
Biological Process
GO:0010025 wax biosynthetic process
GO:0042572 retinol metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3045345
InterPro IPR007130 Diacylglycerol acyltransferase
PFAM PF03982
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6E1M8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 245532
UniGene Mm.118171
RefSeq NP_001277324
MGI ID
MGI Symbol Awat2
OMIM
CCDS CCDS72412
HPRD
IMGT
EMBL AK034920 AY611031 AY611032
GenPept AAT68765 AAT68766 BAC28882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca