Mus musculus Protein: Nt5c2
Summary
InnateDB Protein IDBP-622077.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nt5c2
Protein Name 5'-nucleotidase, cytosolic II
Synonyms 2010002I23Rik; cN-II; CnII; ENSMUSG00000025039; Gm9751; Gmp; Nt5b; Pnt5;
Species Mus musculus
Ensembl Protein ENSMUSP00000129126
InnateDB Gene IDBG-173710 (Nt5c2)
Protein Structure
UniProt Annotation
Function May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0008253 5'-nucleotidase activity
GO:0046872 metal ion binding
Biological Process
GO:0009117 nucleotide metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2178563
InterPro IPR008380 HAD-superfamily hydrolase, subfamily IG, 5\'-nucleotidase
IPR016695 Purine 5\'-nucleotidase
IPR023214 HAD-like domain
PFAM PF05761
PF00702
PF08282
PF13419
PRINTS
PIRSF PIRSF017434
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3V1L4
PhosphoSite PhosphoSite-Q3V1L4
TrEMBL
UniProt Splice Variant
Entrez Gene 76952
UniGene Mm.473499
RefSeq NP_084086
MGI ID
MGI Symbol Nt5c2
OMIM
CCDS CCDS29883
HPRD
IMGT
EMBL AK008045 AK036730 AK132384 AK147901 AK169616 BC064760
GenPept AAH64760 BAB25428 BAC29555 BAE21136 BAE28216 BAE41263