InnateDB Protein
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IDBP-622305.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Syncrip
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Protein Name
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synaptotagmin binding, cytoplasmic RNA interacting protein
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Synonyms
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2610109K23Rik; 4632417O19Rik; GRY-RBP; Nsap1; Nsap1l; pp68;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000134071
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InnateDB Gene
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IDBG-190151 (Syncrip)
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Protein Structure
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Function |
Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. {ECO:0000250}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Isoforms 1 and 2 are expressed predominantly in the nucleoplasm (By similarity). According to PubMed:10734137, isoform 2 is predominantly found in cytoplasm. The tyrosine phosphorylated form bound to RNA is found in microsomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, adipocytes, kidney and testis. {ECO:0000269PubMed:10734137, ECO:0000269PubMed:11773003, ECO:0000269PubMed:9847309}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
109 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1891690
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InterPro |
IPR000504
RNA recognition motif domain
IPR006535
HnRNP R/Q splicing factor
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TMK9
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PhosphoSite |
PhosphoSite-Q7TMK9
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TrEMBL |
G3XA76
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UniProt Splice Variant |
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Entrez Gene |
56403
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UniGene |
Mm.415780
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RefSeq |
NP_001271257
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MGI ID |
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MGI Symbol |
Syncrip
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OMIM |
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CCDS |
CCDS72292
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HPRD |
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IMGT |
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EMBL |
AB035725
AF093821
AF408434
AK034845
AK077588
AK078158
BC004001
BC041148
BC050079
BC055863
BC058807
BC080309
BC108363
CT025673
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GenPept |
AAC62511
AAH04001
AAH41148
AAH50079
AAH55863
AAH58807
AAH80309
AAI08364
AAL11726
BAA88342
BAC28852
BAC36880
BAC37152
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