InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syncrip

Summary

InnateDB Protein

IDBP-622309.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syncrip

Protein Name

synaptotagmin binding, cytoplasmic RNA interacting protein

Synonyms

2610109K23Rik; 4632417O19Rik; GRY-RBP; Nsap1; Nsap1l; pp68;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133649

InnateDB Gene

IDBG-190151 (Syncrip)

Protein Structure

UniProt Annotation

Function

Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself (By similarity). May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain (By similarity). Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 2 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Isoforms 1 and 2 are expressed predominantly in the nucleoplasm (By similarity). According to PubMed:10734137, isoform 2 is predominantly found in cytoplasm. The tyrosine phosphorylated form bound to RNA is found in microsomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in heart, brain, spleen, lung, liver, skeletal muscle, adipocytes, kidney and testis. {ECO:0000269PubMed:10734137, ECO:0000269PubMed:11773003, ECO:0000269PubMed:9847309}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	109 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0008143	poly(A) binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0017148	negative regulation of translation
GO:0070934	CRD-mediated mRNA stabilization
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0070937	CRD-mediated mRNA stability complex
GO:0071013	catalytic step 2 spliceosome
GO:0071204	histone pre-mRNA 3'end processing complex
GO:0097452	GAIT complex