InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cntn1

Summary

InnateDB Protein

IDBP-622355.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cntn1

Protein Name

contactin 1

Synonyms

AW495098; CNTN; F3cam;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133063

InnateDB Gene

IDBG-176351 (Cntn1)

Protein Structure

UniProt Annotation

Function

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. {ECO:0000269PubMed:11395001, ECO:0000269PubMed:14567914, ECO:0000269PubMed:7678967}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0007155	cell adhesion
GO:0007219	Notch signaling pathway
GO:0010628	positive regulation of gene expression
GO:0010765	positive regulation of sodium ion transport
GO:0010976	positive regulation of neuron projection development
GO:0021549	cerebellum development
GO:0031175	neuron projection development

Cellular Component

GO:0005886	plasma membrane
GO:0031225	anchored component of membrane

Protein Structure and Domains

PDB ID

MGI:105980

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P12960