InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Steap2

Summary

InnateDB Protein

IDBP-622731.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Steap2

Protein Name

six transmembrane epithelial antigen of prostate 2

Synonyms

4921538B17Rik; AI930049; AW045895; IPCA-1; IPCA1; PCANAP1; STAMP1; STMP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132501

InnateDB Gene

IDBG-132944 (Steap2)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. {ECO:0000269PubMed:16609065}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000269PubMed:16609065}; Multi-pass membrane protein {ECO:0000269PubMed:16609065}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006893	Golgi to plasma membrane transport
GO:0006897	endocytosis
GO:0009725	response to hormone
GO:0015677	copper ion import
GO:0045055	regulated secretory pathway
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0030173	integral component of Golgi membrane