InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Steap2

Summary

InnateDB Gene

IDBG-132944.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Steap2

Gene Name

six transmembrane epithelial antigen of prostate 2

Synonyms

4921538B17Rik; AI930049; AW045895; IPCA-1; IPCA1; PCANAP1; STAMP1; STMP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000015653

Encoded Proteins

IDBP-132946

six transmembrane epithelial antigen of prostate 2

IDBP-249672

six transmembrane epithelial antigen of prostate 2

IDBP-249674

six transmembrane epithelial antigen of prostate 2

IDBP-249676

six transmembrane epithelial antigen of prostate 2

IDBP-249678

six transmembrane epithelial antigen of prostate 2

IDBP-531875

six transmembrane epithelial antigen of prostate 2

IDBP-622731

six transmembrane epithelial antigen of prostate 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157214:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:5664831-5694578

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015797	ENSMUSP00000015797
ENSMUST00000115427	ENSMUSP00000111087
ENSMUST00000115426	ENSMUSP00000111086
ENSMUST00000115425	ENSMUSP00000111085
ENSMUST00000115424	ENSMUSP00000111084
ENSMUST00000149412
ENSMUST00000148333	ENSMUSP00000116910
ENSMUST00000150238
ENSMUST00000164219	ENSMUSP00000132501

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006893	Golgi to plasma membrane transport
GO:0006897	endocytosis
GO:0009725	response to hormone
GO:0015677	copper ion import
GO:0045055	regulated secretory pathway
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0030173	integral component of Golgi membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000157214

View Gene Order

ENSBTAG00000003506

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_25283

Transferrin endocytosis and recycling pathway

REACT_25060

Iron uptake and transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.274956 Mm.401118 Mm.412621 Mm.469231

RefSeq

NM_001103156 NM_001103157 NM_001285469 NM_001285470 NM_001285471 NM_028734 XM_006503609

OMIM

CCDS

CCDS39007 CCDS71541

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas