Version 5.4
Homo sapiens Protein: APPBP2
Summary
InnateDB Protein IDBP-62309.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APPBP2
Protein Name amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Synonyms APP-BP2; HS.84084; PAT1;
Species Homo sapiens
Ensembl Protein ENSP00000083182
InnateDB Gene IDBG-62307 (APPBP2)
Protein Structure
UniProt Annotation
Function May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface. {ECO:0000269PubMed:9843960}.
Subcellular Localization Nucleus. Cytoplasm, cytoskeleton. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with membranes and microtubules.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0008152 metabolic process
GO:0046907 intracellular transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
PFAM PF13174
PF13176
PF13181
PRINTS
PIRSF
SMART SM00028
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92624
PhosphoSite PhosphoSite-Q92624
TrEMBL K7EIZ9
UniProt Splice Variant
Entrez Gene 10513
UniGene Hs.84084
RefSeq NP_006371
HUGO HGNC:622
OMIM 605324
CCDS CCDS32699
HPRD 05616
IMGT
EMBL AC011921 AC037475 AF017782 AK292227 BC018121 CH471179 D86981
GenPept AAC83973 AAH18121 BAA13217 BAF84916 EAW51406 EAW51407

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca