Version 5.4
Mus musculus Protein: Cotl1
Summary
InnateDB Protein IDBP-623135.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cotl1
Protein Name coactosin-like 1 (Dictyostelium)
Synonyms 1810074P22Rik; 2010004C08Rik; Clp;
Species Mus musculus
Ensembl Protein ENSMUSP00000126329
InnateDB Gene IDBG-195955 (Cotl1)
Protein Structure
UniProt Annotation
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0050832 defense response to fungus
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:1919292
InterPro IPR002108 Actin-depolymerising factor homology domain
PFAM PF00241
PRINTS
PIRSF
SMART SM00102
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CQI6
PhosphoSite PhosphoSite-Q9CQI6
TrEMBL Q544F6
UniProt Splice Variant
Entrez Gene 72042
UniGene Mm.468961
RefSeq
MGI ID 1WM4
MGI Symbol Cotl1
OMIM
CCDS CCDS22712
HPRD
IMGT
EMBL AK007994 AK008085 AK010052 AK039644 AK148854 AK150888 AK151690 AK157694 AK172403 BC010249 BC011068 CT010261
GenPept AAH10249 AAH11068 BAB25396 BAB25450 BAB26668 BAC30407 BAE28680 BAE29935 BAE30614 BAE34154 BAE42989 CAJ18469

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca