InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKQ

Summary

InnateDB Protein

IDBP-6234.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKQ

Protein Name

diacylglycerol kinase, theta 110kDa

Synonyms

DAGK; DAGK4; DAGK7;

Species

Homo sapiens

Ensembl Protein

ENSP00000273814

InnateDB Gene

IDBG-6228 (DGKQ)

Protein Structure

UniProt Annotation

Function

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. {ECO:0000250, ECO:0000269PubMed:17664281}.

Subcellular Localization

Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Note=Translocates to the nucleus in response to thrombin stimulation (By similarity). Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0033613	activating transcription factor binding
GO:0043274	phospholipase binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0035556	intracellular signal transduction
GO:0070493	thrombin receptor signaling pathway
GO:0070528	protein kinase C signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00609
PF00781
PF00130

PRINTS

PIRSF

SMART

SM00314
SM00045
SM00046
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52824