InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DGKQ

Summary

InnateDB Gene

IDBG-6228.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKQ

Gene Name

diacylglycerol kinase, theta 110kDa

Synonyms

DAGK; DAGK4; DAGK7

Species

Homo sapiens

Ensembl Gene

ENSG00000145214

Encoded Proteins

IDBP-6234

diacylglycerol kinase, theta 110kDa

IDBP-484062

diacylglycerol kinase, theta 110kDa

IDBP-484731

diacylglycerol kinase, theta 110kDa

IDBP-479136

diacylglycerol kinase, theta 110kDa

IDBP-806501

diacylglycerol kinase, theta 110kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:958885-986895

Strand

Reverse strand

Band

p16.3

Transcripts

ENST00000273814	ENSP00000273814
ENST00000509465	ENSP00000425862
ENST00000515182	ENSP00000421756
ENST00000502309
ENST00000510286	ENSP00000427268
ENST00000621998	ENSP00000482164

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019900	kinase binding
GO:0033613	activating transcription factor binding
GO:0043274	phospholipase binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0019933	cAMP-mediated signaling
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0035556	intracellular signal transduction
GO:0070493	thrombin receptor signaling pathway
GO:0070528	protein kinase C signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004815

View Gene Order

ENSBTAG00000017240

Not yet available

Pathways

NETPATH

REACTOME

REACT_2202

Effects of PIP2 hydrolysis pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14797

Signaling by GPCR pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_604

Hemostasis pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa00561

Glycerolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.584858

RefSeq

NM_001347 XM_006713863

HUGO

OMIM

CCDS

CCDS3342

HPRD

03127

IMGT

EMBL

GenPept

RNA Seq Atlas