Homo sapiens Gene: DGKQ
Summary
InnateDB Gene IDBG-6228.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DGKQ
Gene Name diacylglycerol kinase, theta 110kDa
Synonyms DAGK; DAGK4; DAGK7;
Species Homo sapiens
Ensembl Gene ENSG00000145214
Encoded Proteins
diacylglycerol kinase, theta 110kDa
diacylglycerol kinase, theta 110kDa
diacylglycerol kinase, theta 110kDa
diacylglycerol kinase, theta 110kDa
diacylglycerol kinase, theta 110kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:958885-986895
Strand Reverse strand
Band p16.3
Transcripts
ENST00000273814 ENSP00000273814
ENST00000509465 ENSP00000425862
ENST00000515182 ENSP00000421756
ENST00000502309
ENST00000510286 ENSP00000427268
ENST00000621998 ENSP00000482164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019900 kinase binding
GO:0033613 activating transcription factor binding
GO:0043274 phospholipase binding
GO:0046872 metal ion binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596 blood coagulation
GO:0016310 phosphorylation
GO:0019933 cAMP-mediated signaling
GO:0030168 platelet activation
GO:0033198 response to ATP
GO:0035556 intracellular signal transduction
GO:0070493 thrombin receptor signaling pathway
GO:0070528 protein kinase C signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Effects of PIP2 hydrolysis pathway
Hemostasis pathway
KEGG
Glycerolipid metabolism pathway
Glycerophospholipid metabolism pathway
Phosphatidylinositol signaling system pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P52824
TrEMBL D6RJB4 H0Y8Q7
UniProt Splice Variant
Entrez Gene 1609
UniGene Hs.584858
RefSeq NM_001347 XM_006713863
HUGO HGNC:2856
OMIM 601207
CCDS CCDS3342
HPRD
IMGT
EMBL AC019103 BC063801 L38707
GenPept AAA98749 AAH63801
RNA Seq Atlas 1609