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InnateDB Protein
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IDBP-62344.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIRT5
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Protein Name
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sirtuin 5
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Synonyms
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SIR2L5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368552
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InnateDB Gene
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IDBG-62340 (SIRT5)
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Protein Structure
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| Function |
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269PubMed:18680753, ECO:0000269PubMed:21908771, ECO:0000269PubMed:22076378, ECO:0000269PubMed:24140062}.
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| Subcellular Localization |
Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.Isoform 1: Cytoplasm {ECO:0000269PubMed:21143562}. Mitochondrion {ECO:0000255HAMAP- Rule:MF_03160, ECO:0000269PubMed:21143562}.Isoform 2: Mitochondrion {ECO:0000255HAMAP- Rule:MF_03160, ECO:0000269PubMed:21143562}.
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| Disease Associations |
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| Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:10381378}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
78
[view]
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| Protein-Protein |
6
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
72
[view]
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
1 [view]
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9NXA8
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| TrEMBL |
Q7Z3A0
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| UniProt Splice Variant |
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| Entrez Gene |
23408
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| UniGene |
Hs.567431
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| RefSeq |
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| HUGO |
HGNC:14933
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| OMIM |
604483
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| CCDS |
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| HPRD |
06838
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| IMGT |
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| EMBL |
BX538030
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| GenPept |
CAD97975
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Version 5.4