|Homo sapiens Gene: SIRT5|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||sirtuin 5|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
|Genomic Location||Chromosome 6:13574529-13615158|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|RefSeq||NM_001193267 NM_001242827 NM_012241 NM_031244 XM_005248967 XM_005248968|
|CCDS||CCDS4526 CCDS4527 CCDS54966 CCDS56398|
|RNA Seq Atlas|