Homo sapiens Gene: SIRT5
Summary
InnateDB Gene IDBG-62340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT5
Gene Name sirtuin 5
Synonyms SIR2L5;
Species Homo sapiens
Ensembl Gene ENSG00000124523
Encoded Proteins
sirtuin 5
sirtuin 5
sirtuin 5
sirtuin 5
sirtuin 5
sirtuin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:13574529-13615158
Strand Forward strand
Band p23
Transcripts
ENST00000379262 ENSP00000368564
ENST00000379250 ENSP00000368552
ENST00000359782 ENSP00000352830
ENST00000397350 ENSP00000380509
ENST00000606427 ENSP00000476211
ENST00000606117 ENSP00000476228
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 72 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006342 chromatin silencing
GO:0006476 protein deacetylation
GO:0036047 peptidyl-lysine demalonylation
GO:0036048 protein desuccinylation
GO:0036049 peptidyl-lysine desuccinylation
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567431
RefSeq NM_001193267 NM_001242827 NM_012241 NM_031244 XM_005248967 XM_005248968
HUGO
OMIM
CCDS CCDS4526 CCDS4527 CCDS54966 CCDS56398
HPRD 06838
IMGT
EMBL
GenPept
RNA Seq Atlas