InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SIRT5

Summary

InnateDB Gene

IDBG-62340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT5

Gene Name

sirtuin 5

Synonyms

SIR2L5

Species

Homo sapiens

Ensembl Gene

ENSG00000124523

Encoded Proteins

IDBP-62342

sirtuin 5

IDBP-62344

sirtuin 5

IDBP-62346

sirtuin 5

IDBP-235561

sirtuin 5

IDBP-812851

sirtuin 5

IDBP-812857

sirtuin 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:13574529-13615158

Strand

Forward strand

Band

p23

Transcripts

ENST00000379262	ENSP00000368564
ENST00000379250	ENSP00000368552
ENST00000359782	ENSP00000352830
ENST00000397350	ENSP00000380509
ENST00000606427	ENSP00000476211
ENST00000606117	ENSP00000476228

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	72 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

Biological Process

GO:0006342	chromatin silencing
GO:0006476	protein deacetylation
GO:0036047	peptidyl-lysine demalonylation
GO:0036048	protein desuccinylation
GO:0036049	peptidyl-lysine desuccinylation
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space
GO:0005759	mitochondrial matrix
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000054021

View Gene Order

ENSBTAG00000014904

Not yet available

Cross-References

SwissProt

Q9NXA8

TrEMBL

A0A024R012 Q7Z3A0 U3KQT8

UniProt Splice Variant

Entrez Gene

23408

UniGene

Hs.567431

RefSeq

NM_001193267 NM_001242827 NM_012241 NM_031244 XM_005248967 XM_005248968

HUGO

HGNC:14933

OMIM

604483

CCDS

CCDS4526 CCDS4527 CCDS54966 CCDS56398

HPRD

IMGT

EMBL

AF083110 AK000355 AK294162 AK302467 AL441883 AM393414 BC000126 BX538030 CH471087

GenPept

AAD40853 AAH00126 BAA91107 BAG57485 BAG63757 CAD97975 CAI19837 CAI19838 CAL38292 EAW55332 EAW55333 EAW55334 EAW55335 EAW55336

RNA Seq Atlas

23408