InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIRT5

Summary

InnateDB Protein

IDBP-62346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT5

Protein Name

sirtuin 5

Synonyms

SIR2L5;

Species

Homo sapiens

Ensembl Protein

ENSP00000352830

InnateDB Gene

IDBG-62340 (SIRT5)

Protein Structure

UniProt Annotation

Function

NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. {ECO:0000269PubMed:18680753, ECO:0000269PubMed:21908771, ECO:0000269PubMed:22076378, ECO:0000269PubMed:24140062}.

Subcellular Localization

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.Isoform 1: Cytoplasm {ECO:0000269PubMed:21143562}. Mitochondrion {ECO:0000255HAMAP- Rule:MF_03160, ECO:0000269PubMed:21143562}.Isoform 2: Mitochondrion {ECO:0000255HAMAP- Rule:MF_03160, ECO:0000269PubMed:21143562}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10381378}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	72 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

Biological Process

GO:0006342	chromatin silencing
GO:0006476	protein deacetylation
GO:0036047	peptidyl-lysine demalonylation
GO:0036048	protein desuccinylation
GO:0036049	peptidyl-lysine desuccinylation
GO:2000378	negative regulation of reactive oxygen species metabolic process