InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: S100a14

Summary

InnateDB Protein

IDBP-623579.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100a14

Protein Name

S100 calcium binding protein A14

Synonyms

1110013O05Rik; S100a15; S114;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126821

InnateDB Gene

IDBG-167833 (S100a14)

Protein Structure

UniProt Annotation

Function

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0042379	chemokine receptor binding

Biological Process

GO:0006915	apoptotic process
GO:0032496	response to lipopolysaccharide
GO:0034142	toll-like receptor 4 signaling pathway
GO:0042742	defense response to bacterium
GO:0071624	positive regulation of granulocyte chemotaxis
GO:0090026	positive regulation of monocyte chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0030054	cell junction
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome