InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rdx

Summary

InnateDB Protein

IDBP-623852.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rdx

Protein Name

radixin

Synonyms

AA516625;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128249

InnateDB Gene

IDBG-165022 (Rdx)

Protein Structure

UniProt Annotation

Function

Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0030033	microvillus assembly
GO:0045176	apical protein localization
GO:0051693	actin filament capping

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0019898	extrinsic component of membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030315	T-tubule
GO:0032154	cleavage furrow
GO:0032420	stereocilium
GO:0045177	apical part of cell
GO:0051286	cell tip

Protein Structure and Domains

PDB ID

MGI:97887

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR013992 Adenylate cyclase-associated CAP, N-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00769
PF01213
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References