Mus musculus Gene: Rdx
Summary
InnateDB Gene IDBG-165022.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rdx
Gene Name radixin
Synonyms AA516625;
Species Mus musculus
Ensembl Gene ENSMUSG00000032050
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137710:
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:52047150-52088737
Strand Forward strand
Band A5.3
Transcripts
ENSMUST00000000590 ENSMUSP00000000590
ENSMUST00000061352 ENSMUSP00000055303
ENSMUST00000163153 ENSMUSP00000128249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0010628 positive regulation of gene expression
GO:0030033 microvillus assembly
GO:0045176 apical protein localization
GO:0051693 actin filament capping
GO:0061028 establishment of endothelial barrier
Cellular Component
GO:0001726 ruffle
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005925 focal adhesion
GO:0019898 extrinsic component of membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030315 T-tubule
GO:0032154 cleavage furrow
GO:0032420 stereocilium
GO:0045177 apical part of cell
GO:0051286 cell tip
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
KitReceptor pathway
REACTOME
Developmental Biology pathway
Axon guidance pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
KEGG
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P26043
TrEMBL Q3TH46 Q3TS74 Q3U111 Q7TSG6
UniProt Splice Variant
Entrez Gene 19684
UniGene Mm.245746 Mm.391690 Mm.408410 Mm.472049
RefSeq NM_001104616 NM_001104617 NM_009041
OMIM
CCDS CCDS40634 CCDS52793
HPRD
IMGT
MGI ID MGI:97887
MGI Symbol Rdx
EMBL AC159881 AK156370 AK162204 AK162224 AK168449 BC053417 CT009732 X60672
GenPept AAH53417 BAE33689 BAE36790 BAE36801 BAE40352 CAA43087
RNA Seq Atlas 19684