InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rdx

Summary

InnateDB Gene

IDBG-165022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rdx

Gene Name

radixin

Synonyms

AA516625

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032050

Encoded Proteins

IDBP-165024

radixin

IDBP-165026

radixin

IDBP-623852

radixin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137710:
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:52047150-52088737

Strand

Forward strand

Band

A5.3

Transcripts

ENSMUST00000000590	ENSMUSP00000000590
ENSMUST00000061352	ENSMUSP00000055303
ENSMUST00000163153	ENSMUSP00000128249

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0010628	positive regulation of gene expression
GO:0030033	microvillus assembly
GO:0045176	apical protein localization
GO:0051693	actin filament capping
GO:0061028	establishment of endothelial barrier

Cellular Component

GO:0001726	ruffle
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0019898	extrinsic component of membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030315	T-tubule
GO:0032154	cleavage furrow
GO:0032420	stereocilium
GO:0045177	apical part of cell
GO:0051286	cell tip
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137710

View Gene Order

ENSBTAG00000004672

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04810

Regulation of actin cytoskeleton pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_6

KitReceptor pathway

REACTOME

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q7TSG6

UniProt Splice Variant

Entrez Gene

19684

UniGene

Mm.245746 Mm.391690 Mm.408410 Mm.472049

RefSeq

NM_001104617 NM_001104616 NM_009041

OMIM

CCDS

CCDS52793 CCDS40634

HPRD

IMGT

MGI ID

MGI:97887

MGI Symbol

Rdx

EMBL

AC159881 BC053417 CT009732

GenPept

AAH53417

RNA Seq Atlas

19684