InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmg20b

Summary

InnateDB Protein

IDBP-623884.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmg20b

Protein Name

high mobility group 20 B

Synonyms

AW610687; BRAF35; Hmgx2; Hmgxb2; Smarce1r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128807

InnateDB Gene

IDBG-178149 (Hmg20b)

Protein Structure

UniProt Annotation

Function

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267}. Chromosome {ECO:0000250}. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed in adult tissues, particularly kidney, skin, testis and uterus. Highly expressed in embryonic tissues with high mitotic index, such as the proliferating ventricular zones of the fore-, mid- and hindbrain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000400	four-way junction DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0033234	negative regulation of protein sumoylation
GO:0035914	skeletal muscle cell differentiation
GO:0045666	positive regulation of neuron differentiation