InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P4hb

Summary

InnateDB Protein

IDBP-624227.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4hb

Protein Name

prolyl 4-hydroxylase, beta polypeptide

Synonyms

ERp59; PDI; Pdia1; Thbp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128796

InnateDB Gene

IDBG-214839 (P4hb)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0016853	isomerase activity
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0006457	protein folding
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005783

endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:97464

InterPro

IPR005788 Disulphide isomerase
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain

PFAM

PF13098
PF13192
PF13462
PF13905
PF00085

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9Q8G8

UniProt Splice Variant

Entrez Gene

18453

UniGene

Mm.16660

RefSeq

MGI ID

MGI Symbol

P4hb

OMIM

CCDS

HPRD

IMGT

EMBL

AL663030

GenPept