Mus musculus Protein: Baat | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-624310.2 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Baat | ||||||||||||||||||||||
Protein Name | bile acid-Coenzyme A: amino acid N-acyltransferase | ||||||||||||||||||||||
Synonyms | AI118337; AI158864; BAT; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000129603 | ||||||||||||||||||||||
InnateDB Gene | IDBG-146969 (Baat) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Cytoplasmic or/and peroxisomal. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in liver, kidney, gallbladder, proximal intestine and distal intestine. Weakly expressed in adrenal gland, lung, brain and muscle. {ECO:0000269PubMed:12810727, ECO:0000269PubMed:9215542}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:106642 | ||||||||||||||||||||||
InterPro |
IPR002925
Dienelactone hydrolase IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal IPR016662 Acyl-CoA thioesterase, long chain IPR029058 Alpha/Beta hydrolase fold |
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PFAM |
PF01738
PF04775 PF08840 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF016521
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SMART | |||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q91X34 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q91X34 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 12012 | ||||||||||||||||||||||
UniGene | Mm.2859 | ||||||||||||||||||||||
RefSeq | XP_006537628 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Baat | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS18173 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK017923 AL772310 BC012683 CH466565 U95215 | ||||||||||||||||||||||
GenPept | AAB58325 BAC25534 CAM21769 EDL02319 | ||||||||||||||||||||||