Mus musculus Gene: Baat
Summary
InnateDB Gene IDBG-146969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Baat
Gene Name bile acid-Coenzyme A: amino acid N-acyltransferase
Synonyms AI118337; AI158864; BAT;
Species Mus musculus
Ensembl Gene ENSMUSG00000039653
Encoded Proteins
bile acid-Coenzyme A: amino acid N-acyltransferase
bile acid-Coenzyme A: amino acid N-acyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136881:
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:49489422-49506557
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000043056 ENSMUSP00000041983
ENSMUST00000166036 ENSMUSP00000129603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0016290 palmitoyl-CoA hydrolase activity
GO:0016410 N-acyltransferase activity
GO:0016787 hydrolase activity
GO:0016790 thiolester hydrolase activity
GO:0047963 glycine N-choloyltransferase activity
GO:0052815 medium-chain acyl-CoA hydrolase activity
GO:0052816 long-chain acyl-CoA hydrolase activity
GO:0052817 very long chain acyl-CoA hydrolase activity
Biological Process
GO:0001889 liver development
GO:0002152 bile acid conjugation
GO:0006544 glycine metabolic process
GO:0006631 fatty acid metabolic process
GO:0006637 acyl-CoA metabolic process
GO:0006699 bile acid biosynthetic process
GO:0008206 bile acid metabolic process
GO:0019530 taurine metabolic process
GO:0031100 organ regeneration
Cellular Component
GO:0005777 peroxisome
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Recycling of bile acids and salts pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Synthesis of bile acids and bile salts pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
KEGG
Primary bile acid biosynthesis pathway
Taurine and hypotaurine metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
Peroxisome pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
Recycling of bile acids and salts pathway
Synthesis of bile acids and bile salts pathway
Metabolism pathway
KEGG
Primary bile acid biosynthesis pathway
Taurine and hypotaurine metabolism pathway
Biosynthesis of unsaturated fatty acids pathway
Peroxisome pathway
Bile secretion pathway
INOH
Methionine Cysteine metabolism pathway
PID BIOCARTA
Metabolism of anandamide an endogenous cannabinoid [Biocarta view]
PID NCI
Cross-References
SwissProt Q91X34
TrEMBL
UniProt Splice Variant
Entrez Gene 12012
UniGene Mm.2859
RefSeq NM_007519
OMIM
CCDS CCDS18173
HPRD
IMGT
MGI ID MGI:106642
MGI Symbol Baat
EMBL AK017923 AL772310 BC012683 CH466565 U95215
GenPept AAB58325 BAC25534 CAM21769 EDL02319
RNA Seq Atlas 12012