InnateDB Protein
|
IDBP-624330.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Rnf20
|
Protein Name
|
ring finger protein 20
|
Synonyms
|
4833430L21Rik; AW540162; C79397; mKIAA4116;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000128546
|
InnateDB Gene
|
IDBG-147129 (Rnf20)
|
Protein Structure
|
|
Function |
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
7
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
30 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1925927
|
InterPro |
IPR001841
Zinc finger, RING-type
IPR015988
STAT transcription factor, coiled coil
|
PFAM |
PF13639
PF14634
|
PRINTS |
|
PIRSF |
|
SMART |
SM00184
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5DTM8
|
PhosphoSite |
PhosphoSite-Q5DTM8
|
TrEMBL |
A2AIR2
|
UniProt Splice Variant |
|
Entrez Gene |
109331
|
UniGene |
Mm.472902
|
RefSeq |
NP_001156735
|
MGI ID |
|
MGI Symbol |
Rnf20
|
OMIM |
|
CCDS |
CCDS18178
|
HPRD |
|
IMGT |
|
EMBL |
AK048862
AK051278
AK053783
AK076501
AK085436
AK139883
AK220492
AL732521
BC052482
|
GenPept |
AAH52482
BAC34590
BAC35521
BAC36367
BAC39446
BAD90290
BAE24170
BAE43337
CAM14732
|
|
|