Mus musculus Gene: Rnf20
Summary
InnateDB Gene IDBG-147129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf20
Gene Name ring finger protein 20
Synonyms 4833430L21Rik; AW540162; C79397; mKIAA4116;
Species Mus musculus
Ensembl Gene ENSMUSG00000028309
Encoded Proteins
ring finger protein 20
ring finger protein 20
ring finger protein 20
ring finger protein 20
ring finger protein 20
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155827:
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:49632006-49656887
Strand Forward strand
Band B1
Transcripts
ENSMUST00000029989 ENSMUSP00000029989
ENSMUST00000140341 ENSMUSP00000121334
ENSMUST00000156314 ENSMUSP00000118293
ENSMUST00000146547 ENSMUSP00000120668
ENSMUST00000132782
ENSMUST00000126675
ENSMUST00000149862
ENSMUST00000131962
ENSMUST00000138490
ENSMUST00000167496 ENSMUSP00000128546
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042393 histone binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0010390 histone monoubiquitination
GO:0016574 histone ubiquitination
GO:0030336 negative regulation of cell migration
GO:0031062 positive regulation of histone methylation
GO:0033523 histone H2B ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0033503 HULC complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24765 Mm.472902
RefSeq NM_001163263 NM_182999 XM_006537553
OMIM
CCDS CCDS18178
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas