InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnnc1

Summary

InnateDB Protein

IDBP-624572.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnnc1

Protein Name

troponin C, cardiac/slow skeletal

Synonyms

AI874626; cTnC; cTnI; TnC; tncc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131991

InnateDB Gene

IDBG-606240 (Tnnc1)

Protein Structure

UniProt Annotation

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031013	troponin I binding
GO:0031014	troponin T binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding
GO:0051015	actin filament binding

Biological Process

GO:0002086	diaphragm contraction
GO:0006937	regulation of muscle contraction
GO:0010038	response to metal ion
GO:0032972	regulation of muscle filament sliding speed
GO:0043462	regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction