InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcne1

Summary

InnateDB Protein

IDBP-625958.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcne1

Protein Name

potassium voltage-gated channel, Isk-related subfamily, member 1

Synonyms

Isk; MinK; nmf190;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130866

InnateDB Gene

IDBG-177593 (Kcne1)

Protein Structure

UniProt Annotation

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Restrictively localized in the apical membrane portion of epithelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0015459	potassium channel regulator activity
GO:0031433	telethonin binding
GO:0046982	protein heterodimerization activity
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process

GO:0002070	epithelial cell maturation
GO:0006487	protein N-linked glycosylation
GO:0006493	protein O-linked glycosylation
GO:0006811	ion transport
GO:0008584	male gonad development
GO:0060047	heart contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071320	cellular response to cAMP
GO:0071435	potassium ion export
GO:0071468	cellular response to acidity
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086013	membrane repolarization during cardiac muscle cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:0090315	negative regulation of protein targeting to membrane
GO:1901381	positive regulation of potassium ion transmembrane transport
GO:1902259	regulation of delayed rectifier potassium channel activity

Cellular Component

GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0008076	voltage-gated potassium channel complex
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030018	Z disc