InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfdp1

Summary

InnateDB Protein

IDBP-626119.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfdp1

Protein Name

transcription factor Dp 1

Synonyms

Dp1; Drtf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127952

InnateDB Gene

IDBG-135121 (Tfdp1)

Protein Structure

UniProt Annotation

Function

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0008544	epidermis development
GO:0043276	anoikis
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000278	regulation of DNA biosynthetic process