Version 5.4
Homo sapiens Protein: DEFB118
Summary
InnateDB Protein IDBP-62652.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEFB118
Protein Name defensin, beta 118
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253381
InnateDB Gene IDBG-62650 (DEFB118)
Protein Structure
UniProt Annotation
Function Has antibacterial activity. {ECO:0000305}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity High-level and epididymis-specific expression. Most abundant in the epithelium of the caput and is also present in the lumen and bound to sperm. Expressed also in pancreas. {ECO:0000269PubMed:12600824}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007283 spermatogenesis
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PH6
PhosphoSite PhosphoSite-Q96PH6
TrEMBL
UniProt Splice Variant
Entrez Gene 117285
UniGene Hs.274124
RefSeq NP_473453
HUGO HGNC:16196
OMIM 607650
CCDS CCDS13177
HPRD 09629
IMGT
EMBL AF347073 AF529415 AL031650 AY122471 BC117378
GenPept AAI17379 AAL27987 AAM93913 AAQ09524 CAI18885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca