InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Actn2

Summary

InnateDB Protein

IDBP-627447.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actn2

Protein Name

actinin alpha 2

Synonyms

1110008F24Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129609

InnateDB Gene

IDBG-129876 (Actn2)

Protein Structure

UniProt Annotation

Function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:19932097}. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0030274	LIM domain binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0030674	protein binding, bridging
GO:0031432	titin binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0051015	actin filament binding
GO:0051373	FATZ binding
GO:0070080	titin Z domain binding

Biological Process

GO:0006936	muscle contraction
GO:0030035	microspike assembly
GO:0042391	regulation of membrane potential
GO:0043267	negative regulation of potassium ion transport
GO:0043268	positive regulation of potassium ion transport
GO:0048041	focal adhesion assembly
GO:0051289	protein homotetramerization
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901018	positive regulation of potassium ion transmembrane transporter activity
GO:2000009	negative regulation of protein localization to cell surface
GO:2000273	positive regulation of receptor activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005865	striated muscle thin filament
GO:0005925	focal adhesion
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0030175	filopodium

Protein Structure and Domains

PDB ID

MGI:109192

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM