Mus musculus Gene: Actn2
Summary
InnateDB Gene IDBG-129876.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Actn2
Gene Name actinin alpha 2
Synonyms 1110008F24Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000052374
Encoded Proteins
actinin alpha 2
actinin alpha 2
actinin alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077522:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. [provided by RefSeq, Jul 2008]
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:12269426-12340760
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000064204 ENSMUSP00000067708
ENSMUST00000110616 ENSMUSP00000106246
ENSMUST00000168193 ENSMUSP00000129609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0030274 LIM domain binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375 thyroid hormone receptor coactivator activity
GO:0030674 protein binding, bridging
GO:0031432 titin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:0046983 protein dimerization activity
GO:0051015 actin filament binding
GO:0051373 FATZ binding
GO:0070080 titin Z domain binding
Biological Process
GO:0006936 muscle contraction
GO:0030035 microspike assembly
GO:0042391 regulation of membrane potential
GO:0043267 negative regulation of potassium ion transport
GO:0043268 positive regulation of potassium ion transport
GO:0048041 focal adhesion assembly
GO:0051289 protein homotetramerization
GO:1901017 negative regulation of potassium ion transmembrane transporter activity
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:2000009 negative regulation of protein localization to cell surface
GO:2000273 positive regulation of receptor activity
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005865 striated muscle thin filament
GO:0005925 focal adhesion
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030175 filopodium
GO:0030864 cortical actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
Nephrin interactions pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Striated Muscle Contraction pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
CREB phosphorylation through the activation of Ras pathway
CREB phosphorylation through the activation of CaMKII pathway
Platelet activation, signaling and aggregation pathway
Post NMDA receptor activation events pathway
Muscle contraction pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Transmission across Chemical Synapses pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Cell-Cell communication pathway
KEGG
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Amoebiasis pathway
Systemic lupus erythematosus pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cell-Cell communication pathway
Nephrin interactions pathway
Neuronal System pathway
Unblocking of NMDA receptor, glutamate binding and activation pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Post NMDA receptor activation events pathway
Ras activation uopn Ca2+ infux through NMDA receptor pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
CREB phosphorylation through the activation of Ras pathway
Response to elevated platelet cytosolic Ca2+ pathway
Transmission across Chemical Synapses pathway
Muscle contraction pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
CREB phosphorylation through the activation of CaMKII pathway
Striated Muscle Contraction pathway
Hemostasis pathway
KEGG
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Amoebiasis pathway
Systemic lupus erythematosus pathway
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
INOH
PID BIOCARTA
Ucalpain and friends in cell spread [Biocarta view]
Integrin signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.37638
RefSeq NM_033268 XM_006516533
OMIM
CCDS CCDS26239
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas