InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Actn2

Summary

InnateDB Gene

IDBG-129876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actn2

Gene Name

actinin alpha 2

Synonyms

1110008F24Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052374

Encoded Proteins

IDBP-129878

actinin alpha 2

IDBP-259883

actinin alpha 2

IDBP-627447

actinin alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077522:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. [provided by RefSeq, Jul 2008]
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:12269426-12340760

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064204	ENSMUSP00000067708
ENSMUST00000110616	ENSMUSP00000106246
ENSMUST00000168193	ENSMUSP00000129609

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0030274	LIM domain binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0030674	protein binding, bridging
GO:0031432	titin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:0046983	protein dimerization activity
GO:0051015	actin filament binding
GO:0051373	FATZ binding
GO:0070080	titin Z domain binding

Biological Process

GO:0006936	muscle contraction
GO:0030035	microspike assembly
GO:0042391	regulation of membrane potential
GO:0043267	negative regulation of potassium ion transport
GO:0043268	positive regulation of potassium ion transport
GO:0048041	focal adhesion assembly
GO:0051289	protein homotetramerization
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901018	positive regulation of potassium ion transmembrane transporter activity
GO:2000009	negative regulation of protein localization to cell surface
GO:2000273	positive regulation of receptor activity
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005865	striated muscle thin filament
GO:0005925	focal adhesion
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0030175	filopodium
GO:0030864	cortical actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000077522

View Gene Order

ENSBTAG00000009696

Not yet available

Pathways

NETPATH

REACTOME

REACT_230203

Platelet degranulation pathway

REACT_224553

Hemostasis pathway

REACT_257032

Nephrin interactions pathway

REACT_203664

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_232053

Striated Muscle Contraction pathway

REACT_198244

Ras activation uopn Ca2+ infux through NMDA receptor pathway

REACT_198246

CREB phosphorylation through the activation of Ras pathway

REACT_198248

CREB phosphorylation through the activation of CaMKII pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_218233

Post NMDA receptor activation events pathway

REACT_262759

Muscle contraction pathway

REACT_259290

Neuronal System pathway

REACT_258217

Unblocking of NMDA receptor, glutamate binding and activation pathway

REACT_206166

Response to elevated platelet cytosolic Ca2+ pathway

REACT_233318

Transmission across Chemical Synapses pathway

REACT_214376

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_223082

Cell-Cell communication pathway

KEGG

mmu04530

Tight junction pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04520

Adherens junction pathway

mmu04670

Leukocyte transendothelial migration pathway

mmu04510

Focal adhesion pathway

mmu05322

Systemic lupus erythematosus pathway

mmu05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

mmu05146

Amoebiasis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_20546

Ras activation uopn Ca2+ infux through NMDA receptor pathway

REACT_20568

CREB phosphorylation through the activation of Ras pathway

REACT_20642

CREB phosphorylation through the activation of CaMKII pathway

REACT_20594

Unblocking of NMDA receptor, glutamate binding and activation pathway

REACT_23832

Nephrin interactions pathway

REACT_16969

Striated Muscle Contraction pathway

REACT_111155

Cell-Cell communication pathway

REACT_13685

Neuronal System pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_20593

Post NMDA receptor activation events pathway

REACT_20563

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_17044

Muscle contraction pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_604

Hemostasis pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04520

Adherens junction pathway

hsa04670

Leukocyte transendothelial migration pathway

hsa04530

Tight junction pathway

hsa04510

Focal adhesion pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

hsa05146

Amoebiasis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.37638

RefSeq

NM_033268 XM_006516533

OMIM

CCDS

CCDS26239

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas