InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il2rb

Summary

InnateDB Protein

IDBP-627507.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il2rb

Protein Name

interleukin 2 receptor, beta chain

Synonyms

CD122; IL-15Rbeta; Il-2/15Rbeta; Il-2Rbeta; IL15Rbeta; p70;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127006

InnateDB Gene

IDBG-159374 (Il2rb)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004911	interleukin-2 receptor activity
GO:0005515	protein binding
GO:0019976	interleukin-2 binding

Biological Process

GO:0038110	interleukin-2-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96550

InterPro

IPR003961 Fibronectin, type III

PFAM

PF00041
PF01108

PRINTS

PIRSF

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P16297

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

16185

UniGene

Mm.35287

RefSeq

MGI ID

MGI Symbol

Il2rb

OMIM

CCDS

CCDS27616

HPRD

IMGT

EMBL

AK017288 AK157572 M28052

GenPept

AAA39283 BAB30674 BAE34125