Version 5.4
Mus musculus Protein: Eps8l1
Summary
InnateDB Protein IDBP-628187.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eps8l1
Protein Name EPS8-like 1
Synonyms 2310051G19Rik; 4632407K17Rik; AW060268; DRC3; EPS8R1;
Species Mus musculus
Ensembl Protein ENSMUSP00000125840
InnateDB Gene IDBG-137784 (Eps8l1)
Protein Structure
UniProt Annotation
Function Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in placenta, skin, mammary gland, bone marrow and stomach. {ECO:0000269PubMed:14565974}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051015 actin filament binding
Biological Process
GO:0016601 Rac protein signal transduction
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1914675
InterPro IPR001452 SH3 domain
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR013761 Sterile alpha motif/pointed domain
PFAM PF00018
PF14604
PF00640
PF14719
PF08416
PRINTS PR00452
PIRSF
SMART SM00326
SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R5F8
PhosphoSite PhosphoSite-Q8R5F8
TrEMBL E9PZ95
UniProt Splice Variant
Entrez Gene 67425
UniGene Mm.360392
RefSeq NP_001277345
MGI ID 2CY5
MGI Symbol Eps8l1
OMIM
CCDS CCDS20736
HPRD
IMGT
EMBL AC161218 AK019490 AY074931 BC027043
GenPept AAL76120 BAB31756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca