InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REM1

Summary

InnateDB Protein

IDBP-62902.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REM1

Protein Name

RAS (RAD and GEM)-like GTP-binding 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000201979

InnateDB Gene

IDBG-62900 (REM1)

Protein Structure

UniProt Annotation

Function

Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.

Subcellular Localization

Disease Associations

Tissue Specificity

Most highly expressed in the endothelial lining of the blood vessels in uterus and heart. Lower levels found in spleen, lymph node, kidney and testis. Also found in cells with secretory function such as the islets of Langerhans, lobule/duct epithelium in the breast, bile duct epithelium in the liver, surface epithelium in the endometrial glands of the uterus, colon mucosa and acinar cells in the pancreas and the prostate.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005516	calmodulin binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0015684	ferrous iron transport

Cellular Component

GO:0005622	intracellular
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR013684 Mitochondrial Rho-like
IPR017358 Small GTPase superfamily, GEM/REM/Rad
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF02421
PF08477

PRINTS

PR00449

PIRSF

PIRSF038017

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References