Version 5.4
Homo sapiens Protein: REV1
Summary
InnateDB Protein IDBP-63379.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REV1
Protein Name REV1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258428
InnateDB Gene IDBG-63377 (REV1)
Protein Structure
UniProt Annotation
Function Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269PubMed:10536157, ECO:0000269PubMed:10760286, ECO:0000269PubMed:11278384, ECO:0000269PubMed:11485998, ECO:0000269PubMed:22266823}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:10536157, ECO:0000269PubMed:11278384, ECO:0000269PubMed:11485998}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0017125 deoxycytidyl transferase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0009411 response to UV
GO:0042276 error-prone translesion synthesis
Cellular Component
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001126 DNA-repair protein, UmuC-like
IPR001357 BRCT domain
IPR012112 DNA repair protein, Rev1
IPR017961 DNA polymerase, Y-family, little finger domain
IPR017963 DNA-repair protein, UmuC-like, N-terminal
PFAM PF00817
PF00533
PF12738
PF11799
PRINTS
PIRSF PIRSF036573
SMART SM00292
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBZ9
PhosphoSite PhosphoSite-Q9UBZ9
TrEMBL
UniProt Splice Variant
Entrez Gene 51455
UniGene Hs.713856
RefSeq NP_057400
HUGO HGNC:14060
OMIM 606134
CCDS CCDS2045
HPRD 16202
IMGT
EMBL AB047646 AC018690 AF151538 AF206019 AF357886 AJ131720 AK002087
GenPept AAF06731 AAF18986 AAK43708 AAY24314 BAA92079 BAB21441 CAB38231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca