Version 5.4
Homo sapiens Gene: REV1
Summary
InnateDB Gene IDBG-63377.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REV1
Gene Name REV1, polymerase (DNA directed)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135945
Encoded Proteins
IDBP-63379
REV1 homolog (S. cerevisiae)
IDBP-243596
REV1 homolog (S. cerevisiae)
IDBP-383563
REV1 homolog (S. cerevisiae)
IDBP-383567
REV1 homolog (S. cerevisiae)
IDBP-383568
REV1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:99400475-99490035
Strand Reverse strand
Band q11.2
Transcripts
ENST00000258428 ENSP00000258428
ENST00000393445 ENSP00000377091
ENST00000413697 ENSP00000416274
ENST00000438366 ENSP00000404213
ENST00000450415 ENSP00000414875
ENST00000482595
ENST00000465086
ENST00000485487
ENST00000465835
ENST00000472000
ENST00000477121
ENST00000481719
ENST00000486117
ENST00000491752
ENST00000482887
ENST00000473819
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0017125 deoxycytidyl transferase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0009411 response to UV
GO:0042276 error-prone translesion synthesis
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026082
View Gene Order
ENSBTAG00000043999
Not yet available
Pathways
NETPATH
REACTOME
REACT_8
Translesion synthesis by HREV1 pathway
REACT_2198
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
REACT_2174
DNA Damage Bypass pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.443077 Hs.713856
RefSeq NM_001037872 NM_016316 XM_005263968 XM_006712592 XM_006712593
HUGO
OMIM
CCDS CCDS2045 CCDS42722
HPRD 16202
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca