Version 5.4
Homo sapiens Protein: TSKS
Summary
InnateDB Protein IDBP-63404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSKS
Protein Name testis-specific serine kinase substrate
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000246801
InnateDB Gene IDBG-63400 (TSKS)
Protein Structure
UniProt Annotation
Function May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:18495105}. Note=Concentrates in spermatid centrioles during flagellogenesis.
Disease Associations
Tissue Specificity Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus. {ECO:0000269PubMed:11444856, ECO:0000269PubMed:15044604}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005814 centriole
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJT2
PhosphoSite PhosphoSite-Q9UJT2
TrEMBL
UniProt Splice Variant
Entrez Gene 60385
UniGene Hs.515858
RefSeq NP_068379
HUGO HGNC:30719
OMIM 608253
CCDS CCDS12780
HPRD 09748
IMGT
EMBL AF200923 AF411384 BC058862
GenPept AAF12819 AAH58862 AAL60464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca