InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP3K3

Summary

InnateDB Protein

IDBP-63436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP3K3

Protein Name

mitogen-activated protein kinase kinase kinase 3

Synonyms

MAPKKK3; MEKK3;

Species

Homo sapiens

Ensembl Protein

ENSP00000354485

InnateDB Gene

IDBG-63432 (MAP3K3)

Protein Structure

UniProt Annotation

Function

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269PubMed:12912994, ECO:0000269PubMed:14661019, ECO:0000269PubMed:14743216, ECO:0000269PubMed:9006902}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	80 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000270 Phox/Bem1p
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00564
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00666
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt