InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DDX42

Summary

InnateDB Protein

IDBP-63649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX42

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

Synonyms

DDX42P; RHELP; RNAHP; SF3b125; SF3B8;

Species

Homo sapiens

Ensembl Protein

ENSP00000352308

InnateDB Gene

IDBG-63647 (DDX42)

Protein Structure

UniProt Annotation

Function

ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269PubMed:16397294, ECO:0000269PubMed:19377511}.

Subcellular Localization

Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.

Disease Associations

Tissue Specificity

Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets. {ECO:0000269PubMed:10727850, ECO:0000269PubMed:16397294}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0008104	protein localization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016020	membrane
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86XP3