Homo sapiens Gene: DDX42
Summary
InnateDB Gene IDBG-63647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX42
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
Synonyms DDX42P; RHELP; RNAHP; SF3b125; SF3B8;
Species Homo sapiens
Ensembl Gene ENSG00000198231
Encoded Proteins
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63773603-63819317
Strand Forward strand
Band q23.3
Transcripts
ENST00000359353 ENSP00000352308
ENST00000389924 ENSP00000374574
ENST00000457800 ENSP00000390121
ENST00000577978
ENST00000579511
ENST00000579539
ENST00000577940 ENSP00000461957
ENST00000583590 ENSP00000463561
ENST00000584010
ENST00000581135 ENSP00000464232
ENST00000580108
ENST00000578593
ENST00000578681 ENSP00000464050
ENST00000584261 ENSP00000462174
ENST00000584951
ENST00000582985
ENST00000581767
ENST00000578137 ENSP00000463038
ENST00000581477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0008104 protein localization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.627787 Hs.690897 Hs.692427 Hs.702010 Hs.731874
RefSeq NM_007372 NM_203499 XM_006721657
HUGO
OMIM
CCDS CCDS32704
HPRD 09909
IMGT
EMBL
GenPept
RNA Seq Atlas