InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMARCD2

Summary

InnateDB Protein

IDBP-63789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCD2

Protein Name

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

Synonyms

BAF60B; CRACD2; Rsc6p;

Species

Homo sapiens

Ensembl Protein

ENSP00000318451

InnateDB Gene

IDBG-63787 (SMARCD2)

Protein Structure

UniProt Annotation

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in the pancreas. {ECO:0000269PubMed:8804307}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0006337	nucleosome disassembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0043044	ATP-dependent chromatin remodeling