InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYLK2

Summary

InnateDB Protein

IDBP-64013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYLK2

Protein Name

myosin light chain kinase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365162

InnateDB Gene

IDBG-64011 (MYLK2)

Protein Structure

UniProt Annotation

Function

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain. {ECO:0000269PubMed:11733062}.

Subcellular Localization

Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.

Disease Associations

Cardiomyopathy, familial hypertrophic (CMH) [MIM:192600]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:11733062}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004687	myosin light chain kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006941	striated muscle contraction
GO:0007274	neuromuscular synaptic transmission
GO:0010628	positive regulation of gene expression
GO:0014816	satellite cell differentiation
GO:0018107	peptidyl-threonine phosphorylation
GO:0032971	regulation of muscle filament sliding
GO:0035914	skeletal muscle cell differentiation
GO:0046777	protein autophosphorylation
GO:0055008	cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030017	sarcomere

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt