Version 5.4
Homo sapiens Gene: MYLK2
Summary
InnateDB Gene IDBG-64011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYLK2
Gene Name myosin light chain kinase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101306
Encoded Proteins
IDBP-64013
myosin light chain kinase 2
IDBP-64015
myosin light chain kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:31819308-31834689
Strand Forward strand
Band q11.21
Transcripts
ENST00000375994 ENSP00000365162
ENST00000375985 ENSP00000365152
ENST00000468730
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004687 myosin light chain kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0006941 striated muscle contraction
GO:0007274 neuromuscular synaptic transmission
GO:0010628 positive regulation of gene expression
GO:0014816 satellite cell differentiation
GO:0018107 peptidyl-threonine phosphorylation
GO:0032971 regulation of muscle filament sliding
GO:0035914 skeletal muscle cell differentiation
GO:0046777 protein autophosphorylation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030017 sarcomere
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000027470
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000014930
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04510
Focal adhesion pathway
hsa04810
Regulation of actin cytoskeleton pathway
hsa04971
Gastric acid secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H1R3
TrEMBL
UniProt Splice Variant
Entrez Gene 85366
UniGene
RefSeq NM_033118
HUGO HGNC:16243
OMIM 606566
CCDS CCDS13191
HPRD
IMGT
EMBL AF325549 AJ272502 AL160175 BC007753 BC069627 BC092413 BC127622
GenPept AAH07753 AAH69627 AAH92413 AAI27623 AAK15494 CAC10006 CAC81354
RNA Seq Atlas 85366

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca