InnateDB Protein
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IDBP-64058.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UCP2
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Protein Name
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uncoupling protein 2 (mitochondrial, proton carrier)
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Synonyms
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BMIQ4; SLC25A8; UCPH;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000312029
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InnateDB Gene
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IDBG-64056 (UCP2)
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Protein Structure
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Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
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Subcellular Localization |
Mitochondrion inner membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
2
[view]
|
RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002030
Mitochondrial brown fat uncoupling protein
IPR018108
Mitochondrial substrate/solute carrier
IPR023395
Mitochondrial carrier domain
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PFAM |
PF00153
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PRINTS |
PR00784
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P55851
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PhosphoSite |
PhosphoSite-P55851
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TrEMBL |
F5H312
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UniProt Splice Variant |
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Entrez Gene |
7351
|
UniGene |
Hs.80658
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RefSeq |
NP_003346
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HUGO |
HGNC:12518
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OMIM |
601693
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CCDS |
CCDS8228
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HPRD |
03410
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IMGT |
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EMBL |
AF019409
AF096289
AJ223477
AJ223478
AJ223479
AK222540
AK222557
AP003717
BC011737
CH471076
DQ087219
U76367
U82819
U94592
|
GenPept |
AAB48411
AAB53091
AAC39690
AAC51336
AAD21151
AAH11737
AAY68217
BAD96260
BAD96277
CAA11402
EAW74923
EAW74924
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