InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UCP2

Summary

InnateDB Gene

IDBG-64056.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCP2

Gene Name

uncoupling protein 2 (mitochondrial, proton carrier)

Synonyms

BMIQ4; SLC25A8; UCPH

Species

Homo sapiens

Ensembl Gene

ENSG00000175567

Encoded Proteins

IDBP-64058

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-601046

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-586673

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-585398

uncoupling protein 2 (mitochondrial, proton carrier)

IDBP-586596

uncoupling protein 2 (mitochondrial, proton carrier)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23988448

MIR133A1 enhances CASP1 activation and IL1B processing and suppresses inflammasome activation by suppressing its target UCP2

Entrez Gene

Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5\'-UCP3-UCP2-3\'. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:73974667-73983307

Strand

Reverse strand

Band

q13.4

Transcripts

ENST00000310473	ENSP00000312029
ENST00000536983	ENSP00000441147
ENST00000544615	ENSP00000439951
ENST00000545212	ENSP00000439706
ENST00000545562
ENST00000543714
ENST00000539764	ENSP00000438230
ENST00000542615
ENST00000541027
ENST00000539330

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000303	response to superoxide
GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006839	mitochondrial transport
GO:0007565	female pregnancy
GO:0007568	aging
GO:0009749	response to glucose
GO:0010942	positive regulation of cell death
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0032869	cellular response to insulin stimulus
GO:0032870	cellular response to hormone stimulus
GO:0034198	cellular response to amino acid starvation
GO:0043066	negative regulation of apoptotic process
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051881	regulation of mitochondrial membrane potential
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070542	response to fatty acid
GO:0071333	cellular response to glucose stimulus
GO:0097421	liver regeneration

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033685

View Gene Order

ENSBTAG00000003692

Not yet available

Pathways

NETPATH

REACTOME

REACT_6258

The fatty acid cycling model pathway

REACT_6196

The proton buffering model pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_6341

Mitochondrial Uncoupling Proteins pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

hnf3bpathway

FOXA2 and FOXA3 transcription factor networks

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.80658

RefSeq

NM_003355

HUGO

OMIM

CCDS

CCDS8228

HPRD

03410

IMGT

EMBL

GenPept

RNA Seq Atlas