Homo sapiens Gene: UCP2
Summary
InnateDB Gene IDBG-64056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCP2
Gene Name uncoupling protein 2 (mitochondrial, proton carrier)
Synonyms BMIQ4; SLC25A8; UCPH;
Species Homo sapiens
Ensembl Gene ENSG00000175567
Encoded Proteins
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
uncoupling protein 2 (mitochondrial, proton carrier)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
MIR133A1 enhances CASP1 activation and IL1B processing and suppresses inflammasome activation by suppressing its target UCP2
Entrez Gene
Summary Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5\'-UCP3-UCP2-3\'. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:73974667-73983307
Strand Reverse strand
Band q13.4
Transcripts
ENST00000310473 ENSP00000312029
ENST00000536983 ENSP00000441147
ENST00000544615 ENSP00000439951
ENST00000545212 ENSP00000439706
ENST00000545562
ENST00000543714
ENST00000539764 ENSP00000438230
ENST00000542615
ENST00000541027
ENST00000539330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000303 response to superoxide
GO:0001666 response to hypoxia
GO:0006810 transport
GO:0006839 mitochondrial transport
GO:0007565 female pregnancy
GO:0007568 aging
GO:0009749 response to glucose
GO:0010942 positive regulation of cell death
GO:0015992 proton transport
GO:0022904 respiratory electron transport chain
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0034198 cellular response to amino acid starvation
GO:0043066 negative regulation of apoptotic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0051881 regulation of mitochondrial membrane potential
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070542 response to fatty acid
GO:0071333 cellular response to glucose stimulus
GO:0097421 liver regeneration
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The proton buffering model pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Mitochondrial Uncoupling Proteins pathway
The fatty acid cycling model pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Cross-References
SwissProt P55851
TrEMBL A0A024R5N5 F5GX45 F5H312 H0YFQ0 H0YFR8
UniProt Splice Variant
Entrez Gene 7351
UniGene Hs.80658
RefSeq NM_003355
HUGO HGNC:12518
OMIM 601693
CCDS CCDS8228
HPRD
IMGT
EMBL AF019409 AF096289 AJ223477 AJ223478 AJ223479 AK222540 AK222557 AP003717 BC011737 CH471076 DQ087219 U76367 U82819 U94592
GenPept AAB48411 AAB53091 AAC39690 AAC51336 AAD21151 AAH11737 AAY68217 BAD96260 BAD96277 CAA11402 EAW74923 EAW74924
RNA Seq Atlas 7351